Hormone-disrupting chemicals found in a variety of consumer products are destroying male reproductive health, according to a report released by the nonprofit CHEM Trust.
An increasing number of widely used chemicals are being exposed as endocrine disruptors, many of them ingredients in plastics, cosmetics, cleaning products and even food. Most of these simulate the action of the female sex hormone estrogen.
According to report author Richard Sharpe of the Medical Research Council, long-term exposure to a wide variety of these chemicals is probably to blame, at least in part, for rising incidence of a condition known as Testicular Dysgenisis Syndrome (TDS). Exposure to endocrine disruptors can “feminize” male children even in the womb, he said, by blocking the activity of the male sex hormone testosterone.
TDS refers to a collection of observed disorders of the male reproductive system, including reduced sperm counts, malformed penis and testicular cancer.
While exposure to one endocrine disruptor might not have a great effect, Sharpe said, there are so many different chemicals out there that their cumulative results must be taken into account.
"Because it is the summation of effect of hormone-disrupting chemicals that is critical, and the number of such chemicals that humans are exposed to is considerable, this provides the strongest possible incentive to minimize human exposure to all relevant hormone disruptors, especially women planning pregnancy, as it is obvious that the higher the exposure the greater the risk," he said."Chemicals that have been shown to act together to affect male reproductive health should have their risks assessed together," said Elizabeth Salter Green of the CHEM Trust.
"Currently that is not the case, and unfortunately chemicals are looked at on an individual basis. Therefore, government assurances that exposures are too low to have any effect just do not hold water because regulators do not take into account the additive actions of hormone disrupting chemicals.""It is high time that public health policy is based on good science and that regulatory authorities have health protection, rather than industry protection, uppermost in mind," she said.
Monday, September 28, 2009
Friday, September 11, 2009
Gene for male infertility found
A GENE more common in men with a shortage of healthy sperm points to a new way to treat some forms of male infertility.
Mohamed Benahmed and colleagues at the University of Lyon in France have discovered that a gene variant that increases production of a protein called tumour necrosis factor- is more common in men with a low sperm count or in men whose sperm lack healthy movement.
The team reckons TNF- lowers sperm count by boosting levels of a hormone that stimulates sperm production only when its levels fall. TNF- may also spark production of substances that damage existing sperm. Drugs that block TNF- may treat these types of infertility.
SOURCE: NEWSCIENTIST.COM
Mohamed Benahmed and colleagues at the University of Lyon in France have discovered that a gene variant that increases production of a protein called tumour necrosis factor- is more common in men with a low sperm count or in men whose sperm lack healthy movement.
The team reckons TNF- lowers sperm count by boosting levels of a hormone that stimulates sperm production only when its levels fall. TNF- may also spark production of substances that damage existing sperm. Drugs that block TNF- may treat these types of infertility.
SOURCE: NEWSCIENTIST.COM
Saturday, August 22, 2009
SCIENTISTS CREATE TEST TUBE SPERM
Breakthrough offers hope of finding cure for male infertility
[Dr. Karim Nayernia]
Scientists have created human sperm in the laboratory for the first time. The extraordinary development, which until a few years ago belonged in the realms of science fiction, raises hopes that infertile men may one day be able to father their own biological children.
The sperm were created in a test tube, from stem cells derived from a five-day-old male embryo. The advance raises ethical questions over the safety of the procedure and the threat it poses to the future role of men. It was also challenged by experts who
claimed the sperm-like cells produced in the experiment were not genuine sperm.
If the finding is confirmed, a single male embryo could, in theory, yield a stem-cell line which when stored could provide an unlimited supply of sperm. Once the stem-cell line was established, there would be no further reproductive need for men. In a briefing on the research, the scientists at Newcastle University and the NorthEast England Stem Cell Institute, led by Professor Karim Nayernia, raise the question of whether their discovery means "the end of men".
They point out that the stem cells from which the sperm were made could only be derived from a male embryo – one containing a Y (male) chromosome – so at least one male would be required.
"However, researchers believe that the issue does need to be debated and legislated for," they said. "As work progresses and results improve at Newcastle and elsewhere it may, in theory, be possible to develop sperm from embryonic stem cell lines which have been stored."
Professor Nayernia said:"In theory it would be possible [to dispense with men], but only if you want to produce a population all the same size and shape [because they have the same male genetic origin]. Personally I cannot see human reproduction as purely a biological process. It has human, emotional, psychological, social and ethical aspects, too. We are doing this research to help infertile men, not to replace a reproductive procedure."
The breakthrough was achieved using stem cells derived from a human embryo which were first developed into germ line stem cells – with half the number of chromosomes – and then prompted to produce sperm which were "fully mature and functional", despite being made in a petri dish rather than the testes of a sexually mature man. The results are reported in the journal Stem Cells and Development.
In a parallel but incomplete experiment, the same group of researchers are creating stem cells out of skin cells from which they have produced sperm, with the same genetic make-up as the skin cells from which they are derived.This would allow infertile men to produce their own biological children, using only their skin cells. Professor Nayernia said the results of this research were "promising" and added: "We hope in a few months to publish that work as well."
However, efforts to produce sperm from female stem cells failed. It had been thought the technique might allow lesbian couples to have their own biological children but the researchers say the genes on the Y (male) chromosome are essential to sperm maturation.
Three years ago, Professor Nayernia led scientists at the University of Gottingen in Germany who became the first to produce viable sperm from mouse embryonic stem cells which were used to produce seven live offspring. However, the baby mice died shortly after birth.
The latest discovery is a further step on the way to finding a cure for male infertility. Under current legislation, researchers are banned from using sperm (or eggs) produced in the laboratory – known as in-vitro derived (IVD) sperm – to treat patients. But it is permitted for research purposes.
"Sperm production takes 15 years in a human and there are thousands of factors that could affect it," said Professor Nayernia. "We can investigate these factors in the laboratory in a matter of months with this technique."
Experts yesterday challenged the Newcastle researchers' claims to have created genuine sperm.
Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield, said: "As a sperm biologist of 20 years' experience, I am unconvinced from the data presented in this paper that the cells produced ... can be accurately called 'Spermatozoa'."
Azim Surani, a professor of physiology and reproduction at the University of Cambridge, said: "These sperm-like cells made in a dish from embryonic stem cells are a long way from being authentic sperm cells." Professor Robin Lovell Badge, from the National Institute for Medical Research, echoed the academic criticisms, but said: "Despite these drawbacks, it may be that the authors have made some progress in obtaining sperm from human embryonic stem cells in vitro.
"This will be very important for research and ultimately, although definitely not yet, for fertility treatments."
Professor Nayernia said his research was submitted as "proof of principle" which needed confirmation by further studies. "Our intention was to open up new avenues of research," he said. "It seems unreasonable to criticise our work on the basis that we have not done more."
The Human Fertilisation and Embryology Authority, which regulates research, has estimated that it will be at least five or 10 years before eggs of sperm could be produced which could potentially be used in treatment.
Before laboratory-produced sperm could be used to make babies for couples who are infertile, the 2008 Human Fertilisation and Embryology Act would have to be changed.
Sperm: The facts
* It takes 10 weeks to make a sperm in the testes.
* Once produced they are stored for about a fortnight.
* If they are not ejaculated they are broken down and reabsorbed.
* A healthy male can produce 70 to 150 million sperm a day.
* A teaspoon can hold 200 to 500 million sperm.
SOURCE: INDEPENDENT.CO.UK
Thursday, July 30, 2009
Foods that will increase the quality and quantity of sperm
Although there is no scientific evidence to prove any of the following claims that are believed to improve the taste of your semen, they are nevertheless widely believed among drinkers and squirters alike.Believe it or not, many of the things that affect body odor are believed to affect the taste of semen as well.
For instance, alcohol and coffee are believed to give semen a bitter, pungent taste. There are many ingredients composing semen, and its makeup is the same from man to man. Here are a few of the constituent elements: vitamin C, calcium, chlorine, cholesterol, citric acid, creatine, fructose, lactic acid, magnesium, nitrogen, phosphorus, potassium, sodium, vitamin B12, and zinc. So what effect will all this have on her waistline? Well, not much of an effect at all. The caloric content of the average ejaculate is estimated to be approximately 5 to 25 calories -- hardly the most fattening meal.
As well, cigarettes, garlic, onions, broccoli, and cauliflower are also believed to alter the taste of your love juice. The cigarettes need no explanation; you're inhaling fire, let's get real. But because the aforementioned foods tend to have a distinct odor, it's believed that they will affect the way you taste.
If you're dehydrated, pig out on spicy foods or are taking medication, these factors may also contribute to an uninviting flavor. So maybe you should take it easy on Mexican delights and start downing water like there's no tomorrow.
What To Eat/Drink:
Plums Oranges Lemons Limes Cilantro Spearmint Grapefruit Green tea Beer Pineapple Mangoes Chamomile tea
What To Avoid:
Broccoli Brussels Sprouts Spices Coffee Chocolate Cigarettes Asparagus Chemically processed liquor Onions Garlic Dairy Products Red meat Considering most guys are avid meat eaters, keep in mind that red meat apparently makes semen taste more acidic. Hmm, nothing like the taste of acid to end off a wonderful night of sexual fun.To sweeten up your inner load, drink plenty of pineapple juice, and eat bananas and papaya. Their sweetness results in yours. And of course, lest we forget that parsley can do wonders for men worldwide -- it eliminates body odor, freshens breath and improves the taste of seminal fluid. Fruits like kiwi, watermelon, celery, and pineapple are all said to make semen taste lighter. Beer and coffee are believed to have something of an opposite effect, and could leave her with a bitter taste in the mouth. Alkaline-based foods like meat and fish produce a buttery taste, while acidic fruits (cranberries, blueberries and plums) produce a pleasant, sugary flavor. Most liqueurs will do the same, while dairy products can make for a foul taste because of their high bacterial putrefaction levels. Always keep in mind that everyone has a distinct taste and even if you do all these things, she might still find the taste of your fluid repulsive. But if she's more than willing and able to sacrifice for the greater good, then have her down a mint before she makes her way down south.The mint will serve to hinder the flavor of your semen and will simultaneously provide you with indescribable sensations.
A lot of guys would love it if they could make like one of the characters in Scary Movie and ejaculate so much that they plaster their girlfriends against the ceiling. And although that won't likely be happening anytime soon, it's believed that wheat germ increases seminal output. Bon appétit.
Amino acids, if taken regularly, are generally believed to increase ejaculate fluid. On the other hand, zinc seems to improve both the amount of sperm produced as well as the sperm's ability to move spontaneously and independently. Together with amino acids, this will increase normal sperm count and volume significantly. Amino acids are believed to increase ejaculate fluid (not the amount of actual sperm necessarily) if taken regularly. Some amino acids include:L-ARGININE HCLStudies show sperm and semen volume doubles, fertility improves (even among men with low sperm counts or poor sperm motility), and sperm health and activity increase with supplementation.
Arginine is found in high concentrations in nuts and seeds like peanuts and almonds. It can also be found in chocolate and raisins. Some Natural Sources: Nuts, sunflower seeds, sesame seeds, chocolate, popcorn, raisins, brown rice, carob, gelatin desserts, oatmeal, whole wheat bread, and protein rich foods.
L-LYSINEResearchers find that this amino acids plus zinc increases sperm produced, stimulates testosterone production, and improves semen quality.EPIMEDIUM SAGITTATUMSometimes called "horny goat weed," this botanical boosts libido and testosterone levels for greater sperm production for a strong ejaculation.
ZINC OXIDEHas been shown to increase number of sperm and sperm motility by 80% to 200% by aiding testosterone synthesis.
L-CARNITINE. This amino acid is found in high concentrations in healthy sperm. Proven to significantly increase the percentage of highly motile sperm.
CATUABA BARKBrazilian herb that strengthens the libido, and nourishes the entire male reproductive system.
PUMPKIN SEED supports prostate health and hormonal production. While they may not readily increase sperm volume, they do enhance prostate health and testosterone production.
MACALegendary South American botanical proven to promote libido, potency and energy.Ginseng Yohimbe barkVitamin C, EMagnesium
Zinc has been shown to improve both the amount of sperm you produce and the sperm's ability to move spontaneously and independently. Coupled with amino acids (see above), this will increase sperm volume significantly.(Butter's note: Not as miraculous as they make it sound, but regular zinc intake (50mgs a day) does increase quantity somewhat.)Whatever a pill company's claims are, you can probably do just as well with zinc and lecithin supplements. (Use zinc supplements in moderation; too much zinc intake can be dangerous.) For some guys, these nutrients do have a noticeable effect on ejaculation volume, and they're a lot cheaper and easier to get.
In general, stay away from mail-order pills sold by less-than-reputable companies; you really don't know what's in them, and their claims are almost always untrue or at least greatly exaggerated.
PC Exercises:While Kegel exercises can help you last longer, they can also aid in increasing sperm volume. There are a host of exercises you can do to keep your penis in great shape and shoot like a champion.
Frequency of sexual activity also contributes to volume -- although only to a certain degree. If you abstain for a day or two, you'll certainly produce more sperm than you would ejaculating every few hours. But any longer than this one- to two-day timeframe, and you won't see much of a difference, as semen reservoirs will have stopped building up a supply.
Consistency of semen isn't very consistent; you've probably noticed that the thickness of your ejaculate can vary from day to day. This is because the quality of the fluid is very susceptible to a number of factors. Diet, exercise and frequency of sex can all dictate how thick or watery your emissions are, as can the tightness of the clothes that you wear (tight clothing will increase body temperature and can thus impact sperm motility.
While there is a lack of supporting scientific evidence, a number of ingredients are said to help thicken up semen. Because of their protein content, egg whites and gelatin are often recommended. Wheat germ, omega-3 oils, selenium, and zinc are all also believed to improve consistency.
A healthy balance of nutrients is important for maintaining vascular health as well, which improves your ability to achieve and maintain erections. There isn't a need to go popping extra vitamins if you are already eating a diet rich in nutrients, particulary from fruits and vegetables. Essential fatty acids are found in certain kinds of fish (like salmon) and nuts.Celery is one of food products known to have great properties for sexual stimulation. It contains androsterone, an odor free hormone which is very inviting for women. Raw celery is the best way to increase that desire. Oysters are rich in zinc and are know to increase sperm and testosterone production. It contains dopamine which increases the sexual desire. Bananas, Avocado and Almond or other nuts are some of the other food products which help in this matter.
Eat Nutritious Food - Diet that's low in fat, and high in protein, vegetables, and whole grains is good for your health and for your sperm. Avoid bitter, astringent and spicy foods.Reduce caffeine intake. Avoid heating of testicles - Wear loose, cotton boxer shorts, Avoid hot baths and saunas.
Lose any excess weight, which tends to cause testosterone/oestrogen imbalances. Reduce stress levels by learning relaxation techniques - Keep your mind and body healthy by regular practice of YOGA and MEDITATION.
Massage body with herbal oil, which improves blood circulation.
Try supplements - Certain natural supplements promise to increase sperm production.
Make love in the early morning or afternoon. Sperm levels are often highest in the mornings.
For instance, alcohol and coffee are believed to give semen a bitter, pungent taste. There are many ingredients composing semen, and its makeup is the same from man to man. Here are a few of the constituent elements: vitamin C, calcium, chlorine, cholesterol, citric acid, creatine, fructose, lactic acid, magnesium, nitrogen, phosphorus, potassium, sodium, vitamin B12, and zinc. So what effect will all this have on her waistline? Well, not much of an effect at all. The caloric content of the average ejaculate is estimated to be approximately 5 to 25 calories -- hardly the most fattening meal.
As well, cigarettes, garlic, onions, broccoli, and cauliflower are also believed to alter the taste of your love juice. The cigarettes need no explanation; you're inhaling fire, let's get real. But because the aforementioned foods tend to have a distinct odor, it's believed that they will affect the way you taste.
If you're dehydrated, pig out on spicy foods or are taking medication, these factors may also contribute to an uninviting flavor. So maybe you should take it easy on Mexican delights and start downing water like there's no tomorrow.
What To Eat/Drink:
Plums Oranges Lemons Limes Cilantro Spearmint Grapefruit Green tea Beer Pineapple Mangoes Chamomile tea
What To Avoid:
Broccoli Brussels Sprouts Spices Coffee Chocolate Cigarettes Asparagus Chemically processed liquor Onions Garlic Dairy Products Red meat Considering most guys are avid meat eaters, keep in mind that red meat apparently makes semen taste more acidic. Hmm, nothing like the taste of acid to end off a wonderful night of sexual fun.To sweeten up your inner load, drink plenty of pineapple juice, and eat bananas and papaya. Their sweetness results in yours. And of course, lest we forget that parsley can do wonders for men worldwide -- it eliminates body odor, freshens breath and improves the taste of seminal fluid. Fruits like kiwi, watermelon, celery, and pineapple are all said to make semen taste lighter. Beer and coffee are believed to have something of an opposite effect, and could leave her with a bitter taste in the mouth. Alkaline-based foods like meat and fish produce a buttery taste, while acidic fruits (cranberries, blueberries and plums) produce a pleasant, sugary flavor. Most liqueurs will do the same, while dairy products can make for a foul taste because of their high bacterial putrefaction levels. Always keep in mind that everyone has a distinct taste and even if you do all these things, she might still find the taste of your fluid repulsive. But if she's more than willing and able to sacrifice for the greater good, then have her down a mint before she makes her way down south.The mint will serve to hinder the flavor of your semen and will simultaneously provide you with indescribable sensations.
A lot of guys would love it if they could make like one of the characters in Scary Movie and ejaculate so much that they plaster their girlfriends against the ceiling. And although that won't likely be happening anytime soon, it's believed that wheat germ increases seminal output. Bon appétit.
Amino acids, if taken regularly, are generally believed to increase ejaculate fluid. On the other hand, zinc seems to improve both the amount of sperm produced as well as the sperm's ability to move spontaneously and independently. Together with amino acids, this will increase normal sperm count and volume significantly. Amino acids are believed to increase ejaculate fluid (not the amount of actual sperm necessarily) if taken regularly. Some amino acids include:L-ARGININE HCLStudies show sperm and semen volume doubles, fertility improves (even among men with low sperm counts or poor sperm motility), and sperm health and activity increase with supplementation.
Arginine is found in high concentrations in nuts and seeds like peanuts and almonds. It can also be found in chocolate and raisins. Some Natural Sources: Nuts, sunflower seeds, sesame seeds, chocolate, popcorn, raisins, brown rice, carob, gelatin desserts, oatmeal, whole wheat bread, and protein rich foods.
L-LYSINEResearchers find that this amino acids plus zinc increases sperm produced, stimulates testosterone production, and improves semen quality.EPIMEDIUM SAGITTATUMSometimes called "horny goat weed," this botanical boosts libido and testosterone levels for greater sperm production for a strong ejaculation.
ZINC OXIDEHas been shown to increase number of sperm and sperm motility by 80% to 200% by aiding testosterone synthesis.
L-CARNITINE. This amino acid is found in high concentrations in healthy sperm. Proven to significantly increase the percentage of highly motile sperm.
CATUABA BARKBrazilian herb that strengthens the libido, and nourishes the entire male reproductive system.
PUMPKIN SEED supports prostate health and hormonal production. While they may not readily increase sperm volume, they do enhance prostate health and testosterone production.
MACALegendary South American botanical proven to promote libido, potency and energy.Ginseng Yohimbe barkVitamin C, EMagnesium
Zinc has been shown to improve both the amount of sperm you produce and the sperm's ability to move spontaneously and independently. Coupled with amino acids (see above), this will increase sperm volume significantly.(Butter's note: Not as miraculous as they make it sound, but regular zinc intake (50mgs a day) does increase quantity somewhat.)Whatever a pill company's claims are, you can probably do just as well with zinc and lecithin supplements. (Use zinc supplements in moderation; too much zinc intake can be dangerous.) For some guys, these nutrients do have a noticeable effect on ejaculation volume, and they're a lot cheaper and easier to get.
In general, stay away from mail-order pills sold by less-than-reputable companies; you really don't know what's in them, and their claims are almost always untrue or at least greatly exaggerated.
PC Exercises:While Kegel exercises can help you last longer, they can also aid in increasing sperm volume. There are a host of exercises you can do to keep your penis in great shape and shoot like a champion.
Frequency of sexual activity also contributes to volume -- although only to a certain degree. If you abstain for a day or two, you'll certainly produce more sperm than you would ejaculating every few hours. But any longer than this one- to two-day timeframe, and you won't see much of a difference, as semen reservoirs will have stopped building up a supply.
Consistency of semen isn't very consistent; you've probably noticed that the thickness of your ejaculate can vary from day to day. This is because the quality of the fluid is very susceptible to a number of factors. Diet, exercise and frequency of sex can all dictate how thick or watery your emissions are, as can the tightness of the clothes that you wear (tight clothing will increase body temperature and can thus impact sperm motility.
While there is a lack of supporting scientific evidence, a number of ingredients are said to help thicken up semen. Because of their protein content, egg whites and gelatin are often recommended. Wheat germ, omega-3 oils, selenium, and zinc are all also believed to improve consistency.
A healthy balance of nutrients is important for maintaining vascular health as well, which improves your ability to achieve and maintain erections. There isn't a need to go popping extra vitamins if you are already eating a diet rich in nutrients, particulary from fruits and vegetables. Essential fatty acids are found in certain kinds of fish (like salmon) and nuts.Celery is one of food products known to have great properties for sexual stimulation. It contains androsterone, an odor free hormone which is very inviting for women. Raw celery is the best way to increase that desire. Oysters are rich in zinc and are know to increase sperm and testosterone production. It contains dopamine which increases the sexual desire. Bananas, Avocado and Almond or other nuts are some of the other food products which help in this matter.
Eat Nutritious Food - Diet that's low in fat, and high in protein, vegetables, and whole grains is good for your health and for your sperm. Avoid bitter, astringent and spicy foods.Reduce caffeine intake. Avoid heating of testicles - Wear loose, cotton boxer shorts, Avoid hot baths and saunas.
Lose any excess weight, which tends to cause testosterone/oestrogen imbalances. Reduce stress levels by learning relaxation techniques - Keep your mind and body healthy by regular practice of YOGA and MEDITATION.
Massage body with herbal oil, which improves blood circulation.
Try supplements - Certain natural supplements promise to increase sperm production.
Make love in the early morning or afternoon. Sperm levels are often highest in the mornings.
Friday, June 26, 2009
EMD Serono launches male fertility education campaign
EMD Serono is partnering with Men's Health Network on a patient education campaign aimed at raising awareness of male infertility.The effort, dubbed “In The Know: What No One Tells You About Male Fertility,” is launching this week, which is Men's Health Week. The campaign features a 20-page booklet written in conjunction with the Society for the Study of Male Reproduction, a website (www.FertilityLifeLines.com/intheknow) and a PR campaign by Baer Consulting. It's being supported by a satellite media tour, and aimed at reaching couples through health titles and local news outlets. FertilityLifeLines.com is EMD Serono's fertility awareness site, and includes branding for Gonal-f, a hormone treatment indicated for both male and female infertility. Patients can get the booklet by registering at the site or by calling a toll-free number. EMD Serono reps are distributing copies to reproductive endocrinologists, and the company is promoting it online through search engine optimization and banner ads. As part of the effort, EMD Serono and Men's Health Network are touting a survey finding that 45% of men say they would wait a year or more to seek treatment for an infertility problem. Men are much less likely to present than women, said EVP, endocrinology David Stern, and for women in their late 30s and older, time is critical."Some of this is embarassment," said Stern. "It's important to talk about it. It's not something that makes you less manly. It's common and can be treated."About one in eight couples – around 7.3 million Americans -- has trouble conceiving, the company said, and half of those cases have to do with male fertility issues – often easily treatable ones. The campaign grew out of an earlier “girlfriend-to-girlfriend” effort, aimed at women and based on research conducted with Conceive Magazine, that launched last year.
SOURCE: MMONLINE.COM
Wednesday, June 24, 2009
SSRI ANTIDEPRESSANTS LINKED TO MALE INFERTILITY
The Food and Drug Administration (FDA) issued a warning a few years ago that pregnant women taking the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine risk giving birth to infants with major birth defects, including heart abnormalities.
Now comes word that the same drug (sold as Paxil, Paxil CR, Seroxat, Pexeva, and generic paroxetine hydrochloride) carries another danger that could keep babies from being born in the first place. A new study just published in the online edition of the journal Fertility and Sterility concludes as many as fifty percent of all men taking the antidepressant could have damaged sperm and compromised fertility.
New York Presbyterian Hospital and Weill Cornell Medical Center researchers followed 35 healthy male volunteers who took paroxetine for five weeks. Then sperm samples from the men were studied using an assay called terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) to evaluate whether there were missing pieces of genetic code in the sperm DNA.
This condition, known as DNA fragmentation, is associated with reproductive problems.The results? The percentage of men with abnormal DNA fragmentation soared from less than 10 percent to 50 percent while taking the antidepressant. This is a crucial finding because DNA fragmentation has long been known to correlate with an increased risk of birth defects, poor fertility and unsuccessful pregnancy outcomes -- even when high tech, extraordinarily expensive fertility enhancing techniques such as in vitro fertilization and intracytoplasmic sperm injection are used.
The study, one of the first scientific investigations into the effect of SSRIs on sperm quality, also confirmed that paroxetine impairs sexual function. More than a third of the research subjects reported significant changes in erectile function and about half had difficulty ejaculating.
"It's fairly well known that SSRI antidepressants negatively impact erectile function and ejaculation. This study goes one step further, demonstrating that they can cause a major increase in genetic damage to sperm," Dr. Peter Schlegel, the study's senior author and chairman of the Department of Urology and professor of reproductive medicine at Weill Cornell Medical College, explained in a statement to the media.
"Although this study doesn't look directly at fertility, we can infer that as many as half of men taking SSRIs have a reduced ability to conceive. These men should talk with their physician about their treatment options, including non-SSRI depression medications."The scientists could not identify the exact way the SSRI caused the DNA fragmentation, but the evidence strongly suggests the drug slows sperm as it moves through the male reproductive tract from the testis to the ejaculatory ducts. When this happens, the sluggish sperm grows old and its DNA becomes damaged.
"This is a new concept for how drugs can affect fertility and sperm. In most cases, it was previously assumed that a drug damaged sperm production, so the concept that sperm transport could be affected is novel," Dr. Schlegel stated.The study contains some good news for men currently on Paxil and related drugs who may be concerned about their fertility. All the changes the researchers found appeared to be totally reversible. Specifically, normal levels of sexual function and DNA fragmentation both returned to normal one month after discontinuation of the drug.
SOURCE: NATURALNEWS.COM
Now comes word that the same drug (sold as Paxil, Paxil CR, Seroxat, Pexeva, and generic paroxetine hydrochloride) carries another danger that could keep babies from being born in the first place. A new study just published in the online edition of the journal Fertility and Sterility concludes as many as fifty percent of all men taking the antidepressant could have damaged sperm and compromised fertility.
New York Presbyterian Hospital and Weill Cornell Medical Center researchers followed 35 healthy male volunteers who took paroxetine for five weeks. Then sperm samples from the men were studied using an assay called terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) to evaluate whether there were missing pieces of genetic code in the sperm DNA.
This condition, known as DNA fragmentation, is associated with reproductive problems.The results? The percentage of men with abnormal DNA fragmentation soared from less than 10 percent to 50 percent while taking the antidepressant. This is a crucial finding because DNA fragmentation has long been known to correlate with an increased risk of birth defects, poor fertility and unsuccessful pregnancy outcomes -- even when high tech, extraordinarily expensive fertility enhancing techniques such as in vitro fertilization and intracytoplasmic sperm injection are used.
The study, one of the first scientific investigations into the effect of SSRIs on sperm quality, also confirmed that paroxetine impairs sexual function. More than a third of the research subjects reported significant changes in erectile function and about half had difficulty ejaculating.
"It's fairly well known that SSRI antidepressants negatively impact erectile function and ejaculation. This study goes one step further, demonstrating that they can cause a major increase in genetic damage to sperm," Dr. Peter Schlegel, the study's senior author and chairman of the Department of Urology and professor of reproductive medicine at Weill Cornell Medical College, explained in a statement to the media.
"Although this study doesn't look directly at fertility, we can infer that as many as half of men taking SSRIs have a reduced ability to conceive. These men should talk with their physician about their treatment options, including non-SSRI depression medications."The scientists could not identify the exact way the SSRI caused the DNA fragmentation, but the evidence strongly suggests the drug slows sperm as it moves through the male reproductive tract from the testis to the ejaculatory ducts. When this happens, the sluggish sperm grows old and its DNA becomes damaged.
"This is a new concept for how drugs can affect fertility and sperm. In most cases, it was previously assumed that a drug damaged sperm production, so the concept that sperm transport could be affected is novel," Dr. Schlegel stated.The study contains some good news for men currently on Paxil and related drugs who may be concerned about their fertility. All the changes the researchers found appeared to be totally reversible. Specifically, normal levels of sexual function and DNA fragmentation both returned to normal one month after discontinuation of the drug.
SOURCE: NATURALNEWS.COM
Wednesday, April 15, 2009
Man fathers 'miracle' child using sperm frozen 22 years ago
A man who had his sperm frozen while suffering leukaemia as a teenager has fathered a child after doctors successfully thawed his sample a record 22 years later.
Chris Biblis was advised to have his sperm frozen before undergoing radiotherapy that would leave him sterile at age 16.
He survived the cancer and at age 38 has become the father of a healthy baby daughter, Stella.
She was conceived after scientists injected a defrosted sperm into an egg from Mr Biblis's wife, Melodie, and implanted it in her uterus.
The 22-year lapse between storage in April 1986 and conception in June 2008 is the longest on record, according to specialists at the US fertility clinic who carried out the procedure.
“From my life being saved to being able to create a life, words just can’t describe where we are now,” Mr Biblis, of Charlotte, North Carolina, told ABC news.
“I’ve got this bundle of joy to appreciate. It’s truly a miracle."
The case is being hailed as an illustration of how far infertility treatment has advanced in the past two decades. The previous record was 21 years.
"We believe this is a world record," said Bonnie Schwab of Vanguard Communications in Colorado, which represents the Charlotte doctors.
Even the thought of freezing sperm was unusual in the 1980s, said Dr. Richard Wing, the Biblises' doctor and founder of the Charlotte fertility clinic.
The couple have five frozen embryos and some of Chris Biblis' remaining frozen sperm in the bank if they want to have more children.
SOURCE: telegraph.co.uk
Chris Biblis was advised to have his sperm frozen before undergoing radiotherapy that would leave him sterile at age 16.
He survived the cancer and at age 38 has become the father of a healthy baby daughter, Stella.
She was conceived after scientists injected a defrosted sperm into an egg from Mr Biblis's wife, Melodie, and implanted it in her uterus.
The 22-year lapse between storage in April 1986 and conception in June 2008 is the longest on record, according to specialists at the US fertility clinic who carried out the procedure.
“From my life being saved to being able to create a life, words just can’t describe where we are now,” Mr Biblis, of Charlotte, North Carolina, told ABC news.
“I’ve got this bundle of joy to appreciate. It’s truly a miracle."
The case is being hailed as an illustration of how far infertility treatment has advanced in the past two decades. The previous record was 21 years.
"We believe this is a world record," said Bonnie Schwab of Vanguard Communications in Colorado, which represents the Charlotte doctors.
Even the thought of freezing sperm was unusual in the 1980s, said Dr. Richard Wing, the Biblises' doctor and founder of the Charlotte fertility clinic.
The couple have five frozen embryos and some of Chris Biblis' remaining frozen sperm in the bank if they want to have more children.
SOURCE: telegraph.co.uk
Subscribe to:
Comments (Atom)
